Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.

Science (New York, N.Y.) - 26 Nov 2010

Culler Stephanie J, Hoff Kevin G, Smolke Christina D

Abstract excerpt

Synthetic genetic devices that interface with native cellular pathways can be used to change natural networks to implement new forms of control and behavior. The engineering of gene networks has been limited by an inability to interface with native components. We describe a class of RNA control devices that overcome these limitations by coupling increased abundance of particular proteins to targeted gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to Capsid Proteins
Share to Ganciclovir

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to NF-kappa B p50 Subunit

Share to Survival of Motor Neuron 1 Protein

Share to Transcription Factor RelA

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21109673
DOI: 10.1126/science.1192128
PMCID: PMC3171693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.PMID 21109673Read ↗

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian CellsSemantic proximity Read ↗

A synthetic transcription platform for programmable gene expression in mammalian cellsSemantic proximity Read ↗

Programmable eukaryotic protein expression with RNA sensorsSemantic proximity Read ↗

Programming gene and engineered-cell therapies with synthetic biologySemantic proximity Read ↗

Modular and programmable RNA sensing using ADAR editing in living cellsSemantic proximity Read ↗

Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuliSemantic proximity Read ↗

Multidimensional control of therapeutic human cell function with synthetic gene circuitsSemantic proximity Read ↗

Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals.Semantic proximity Read ↗

Programmable synthetic receptors: the next-generation of cell and gene therapiesSemantic proximity Read ↗

Small-molecule inducible transcriptional control in mammalian cellsSemantic proximity Read ↗

Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic ReprogrammingSemantic proximity Read ↗

Engineering synthetic phosphorylation signaling networks in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.