Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal.

Abstract excerpt

Wnts are evolutionarily conserved signaling proteins with essential roles in development and disease that have often been thought to spread between cells and signal at a distance. However, recent studies have challenged this model, and whether long-distance extracellular Wnt dispersal occurs and is biologically relevant is debated. Understanding fundamental aspects of Wnt dispersal has been limited by challenges...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to beta Catenin
• Share to Caenorhabditis elegans
• Share to Cell Polarity