Article

Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasis

2020-11-23

Abstract excerpt

<title>Abstract</title> <p>To identify genetic events driving breast cancer progression, we performed multi-omics integrated analyses that identified overexpression of nucleoporin-93, a nuclear pore component. Here we show that NUP93 overexpression enhances trans-endothelial migration and matrix invasion in vitro, along with metastasis in animal models. These findings were supported by analyses of naturally occur...

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Literature Corpus work: 44818e15-a71d-526e-8fef-3664dcb7b1ca
DOI: 10.21203/rs.3.rs-100544/v1

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