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Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells.

eLife - 11 Jan 2022

Ambrosi Giulia, Voloshanenko Oksana, Eckert Antonia F, Kranz Dominique, Nienhaus G Ulrich, Boutros Michael

Abstract excerpt

Wnt signaling plays important roles in development, homeostasis, and tumorigenesis. Mutations in β-catenin that activate Wnt signaling have been found in colorectal and hepatocellular carcinomas. However, the dynamics of wild-type and mutant forms of β-catenin are not fully understood. Here, we genome-engineered fluorescently tagged alleles of endogenous β-catenin in a colorectal cancer cell line. Wild-type and...

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Identifiers

PMID: 35014953
DOI: 10.7554/eLife.64498
PMCID: PMC8752093

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