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Article

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.

Journal of neuroinflammation - 28 Jun 2021

Wang Meng, Feng Li-Rong, Li Zi-Long, Ma Kai-Ge, Chang Ke-Wei, Chen Xin-Lin, Yang Peng-Bo, Ji Sheng-Feng, Ma Yan-Bing, Han Hua, Ruganzua John Bosco, Yang Wei-Na, Qian Yi-Hua

Abstract excerpt

BACKGROUND: Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells. While its effects in multiple organs and diseases are being widely investigated, the safety profile has been established in animals and humans, currently, little is known about its influence on Alzheimer's disease (AD) and the possible mechanisms....

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Identifiers

PMID: 34183019
DOI: 10.1186/s12974-021-02166-3
PMCID: PMC8240373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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