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The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease

11 Aug 2022

Abstract excerpt

Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a high prevalence that is expected to double every 20 years. Besides the formation of Aβ plaques and neurofibrillary tangles, neuroinflammation is one the major phenotypes that worsens AD progression. Indeed, the nuclear factor-κB (NF-κB) is a well-established inflammatory transcription factor that fuels neurodegeneration. Thus,...

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PMID: 36012242
DOI: 10.3390/ijms23168972

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