Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target.

Scientific reports - 25 Jun 2021

Takenaga Keizo, Koshikawa Nobuko, Akimoto Miho, Tatsumi Yasutoshi, Lin Jason, Itami Makiko, Nagase Hiroki

Abstract excerpt

Pathogenic mitochondrial NADH dehydrogenase (ND) gene mutations enhance the invasion and metastasis of various cancer cells, and they are associated with metastasis in human non-small cell lung cancer (NSCLC). Moreover, monocarboxylate transporter 4 (MCT4) is overexpressed in solid cancers and plays a role in cancer cell proliferation and survival. Here, we report that MCT4 is exclusively expressed in mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Proliferation

Share to Lung Neoplasms

Share to Monocarboxylic Acid Transporters

Share to Muscle Proteins

Share to NADH Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 34172808
DOI: 10.1038/s41598-021-92772-1
PMCID: PMC8233425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target.PMID 34172808Read ↗

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolismSemantic proximity Read ↗

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressorSemantic proximity Read ↗

SYVN1-mediated ubiquitylation directs the localization of MCT4 in plasma membrane to promote the progression of lung adenocarcinomaSemantic proximity Read ↗

Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors.Semantic proximity Read ↗

Loss of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasisSemantic proximity Read ↗

Mitochondrial metabolism as a potential novel therapeutic target for lung adenocarcinomaSemantic proximity Read ↗

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor MicroenvironmentSemantic proximity Read ↗

Impaired oxidative phosphorylation drives primary tumor escape and metastasisSemantic proximity Read ↗

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer.Semantic proximity Read ↗

Mitochondrial dysfunction induces the invasive phenotype, and cell migration and invasion, through the induction of AKT and AMPK pathways in lung cancer cells.Semantic proximity Read ↗

Roles of MT-ND1 in Cancer.Semantic proximity Read ↗

A novel function of mtDNA: its involvement in metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.