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Article

Mitochondrial dysfunction induces the invasive phenotype, and cell migration and invasion, through the induction of AKT and AMPK pathways in lung cancer cells.

International journal of molecular medicine - 1 Sept 2018

Han Si-Yoon, Jeong Yun-Jeong, Choi Yongsoo, Hwang Soon-Kyung, Bae Young-Seuk, Chang Young-Chae

Abstract excerpt

Mitochondria are well known for their important roles in oxidative phosphorylation, amino acid metabolism, fatty acid oxidation and ion homeostasis. Although the effects of mitochondrial dysfunction on tumorigenesis in various cancer cells have been reported, the correlation between mitochondrial dysfunction and epithelial‑to‑mesenchymal transition (EMT) in lung cancer development and metastasis has not been well...

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Identifiers

PMID: 29916527
DOI: 10.3892/ijmm.2018.3733

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