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Strand discrimination in DNA mismatch repair

19 Jun 2021

Abstract excerpt

DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS and MutL homolog-dependent MMR, damaged bases do not identify the error-containing daughter strand that must be excised and resynthesized. In organisms like Escherichia coli that use methyl-directed MMR, transient undermethylation identifies...

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PMID: 34171627
DOI: 10.1016/j.dnarep.2021.103161

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