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Differential correction of lagging-strand replication errors made by DNA polymerases α and δ

1 Nov 2010

Abstract excerpt

Mismatch repair (MMR) of replication errors requires DNA ends that can direct repair to the newly synthesized strand containing the error. For all but those organisms that use adenine methylation to generate nicks, the source of these ends in vivo is unknown. One possibility is that MMR may have a "special relation to the replication complex" [Wagner R, Jr., Meselson M (1976) Proc Natl Acad Sci USA 73:4135-4139],...

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PMID: 21041657
DOI: 10.1073/pnas.1013048107

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