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Integrative Cistromic and Transcriptomic Analyses Identify CREB Target Genes in Cystic Renal Epithelial Cells

23 Jun 2021

Abstract excerpt

Significance Statement Transcription factors (TFs) play crucial roles in kidney development and diseases by recognizing specific DNA sequences to control gene expression programs. The kidney’s cellular heterogeneity poses substantial challenges to identifying the genomic binding sites and direct target genes of TFs in vivo . We apply the cleavage under targets and release using nuclease (CUT&RUN) technique,...

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Share to Cystic Fibrosis Research Advances
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PMID: 34162733
DOI: 10.1681/asn.2021010101

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