Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.

American journal of physiology. Renal physiology - 1 Mar 2010

Yu Zhiyuan, Kong Qun, Kone Bruce C

Abstract excerpt

Connective tissue growth factor (CTGF) participates in diverse fibrotic processes including glomerulosclerosis. The adenylyl cyclase agonist forskolin inhibits CTGF expression in mesangial cells by unclear mechanisms. We recently reported that the histone H3K79 methyltransferase disruptor of telomeric silencing-1 (Dot1) suppresses CTGF gene expression in collecting duct cells (J Clin Invest 117: 773-783, 2007)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Assembly and Disassembly
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colforsin

Share to Connective Tissue Growth Factor

Share to Cyclic AMP Response Element-Binding Protein

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 20053791
DOI: 10.1152/ajprenal.00636.2009
PMCID: PMC2838603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.PMID 20053791Read ↗

An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.Semantic proximity Read ↗

Integrative Cistromic and Transcriptomic Analyses Identify CREB Target Genes in Cystic Renal Epithelial CellsSemantic proximity Read ↗

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.Semantic proximity Read ↗

Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.Semantic proximity Read ↗

Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain.Semantic proximity Read ↗

Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer.Semantic proximity Read ↗

Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.Semantic proximity Read ↗

Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in ThyrotrophSemantic proximity Read ↗

Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.Semantic proximity Read ↗

Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity.Semantic proximity Read ↗

Identification of the functional domains of the transcriptional regulator CRE-BP1.Semantic proximity Read ↗

Cooperating nonconsensus cAMP-responsive elements are mediators of adrenocorticotropin-induced VL30 transcription in steroidogenic adrenal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.