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Article

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells

8 Jun 2015

Abstract excerpt

Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulators and transcriptional machinery, leading to fine-tuned control of vectorial ionic transport in the distal nephron. To identify genome-wide aldosterone-regulated MR targets in human renal cells, we set up a chromatin...

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PMID: 26054365
DOI: 10.1096/fj.15-274266

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