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Article

Polycystin-1 cleavage and the regulation of transcriptional pathways.

Pediatric nephrology (Berlin, Germany) - 1 Apr 2014

Merrick David, Bertuccio Claudia A, Chapin Hannah C, Lal Mark, Chauvet Veronique, Caplan Michael J

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end-stage renal disease, affecting approximately 1 in 1,000 people. The disease is characterized by the development of numerous large fluid-filled renal cysts over the course of decades. These cysts compress the surrounding renal parenchyma and impair its function. Mutations in two genes are responsible for ADPKD. The protein...

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Identifiers

PMID: 23824180
DOI: 10.1007/s00467-013-2548-y
PMCID: PMC3844055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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