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Article

Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2012

Aguiari Gianluca, Bizzarri Fabiana, Bonon Anna, Mangolini Alessandra, Magri Eros, Pedriali Massimo, Querzoli Patrizia, Somlo Stefan, Harris Peter C, Catizone Luigi, Del Senno Laura

Abstract excerpt

In autosomal dominant polycystic kidney disease (ADPKD), renal cyst development and enlargement, as well as cell growth, are associated with alterations in several pathways, including cAMP and activator protein 1 (AP1) signalling. However, the precise mechanism by which these molecules stimulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22570239
DOI: 10.1007/s00109-012-0902-3
PMCID: PMC4028691

Genes

EGFR
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22570239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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