HDAC6-Mediated FoxO1 Acetylation And Phosphorylation Control Periodontal Inflammatory Responses

Abstract excerpt

Post-translational modifications (PTMs) are critical regulators of protein function and cellular signaling. While histone deacetylation by histone deacetylases (HDACs) is well established, the role of specific HDACs in modulating non-histone protein PTMs, particularly in an infectious context, is poorly understood. Here, we reveal a pivotal role for HDAC6 in orchestrating periodontal inflammation through its dual...

Topics

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• Cytomegalovirus and herpesvirus research
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research
• Oral Health Pathology and Treatment
• Oral microbiology and periodontitis research
• Peptidase Inhibition and Analysis
• Sirtuins and Resveratrol in Medicine
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

abce8a30-89f1-5c46-9593-30985c2cdc38

DOI

10.1101/2024.12.10.627820