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Article

IL-37 blocks gouty inflammation by shaping macrophages into a non-inflammatory phagocytic phenotype.

Rheumatology (Oxford, England) - 30 Aug 2022

Zhao Li, Zhao Tianyi, Yang Xue, Cao Ling, Xu Rui, Liu Jiyu, Lin Cong, Yu Yiyun, Xuan Dandan, Zhu Xiaoxia, Liu Lei, Hua Yinghui, Deng Chunhui, Wan Weiguo, Zou Hejian, Xue Yu

Abstract excerpt

OBJECTIVE: Interleukin (IL)-37 is a natural suppressor of inflammation. Macrophages play an important role in acute gout flare by dominating the inflammation and spontaneous relief. We have reported that IL-37 could limit runaway inflammation in gout. Here we focus on whether IL-37 inhibits gouty inflammation by altering macrophage functions, and how it does so. METHODS: Macrophage functions were evaluated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35015844
DOI: 10.1093/rheumatology/keac009

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