A genome-wide MAGIC kit for recombinase-independent mosaic analysis in <i>Drosophila</i>

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic analysis has been instrumental in advancing developmental and cell biology. Most current mosaic techniques rely on exogenous site-specific recombination sequences that need to be introduced into the genome, limiting their application. Mosaic analysis by gRNA-induced crossing-over (MAGIC) was recently developed in Drosophila to eliminate this requirement by inducing somatic recombination...

Topics

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• CRISPR-Cas Systems
• Crossing Over, Genetic
• Embryo, Nonmammalian
• Gene Editing
• Gene Targeting
• Genome, Insect
• Mosaicism
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

127ea759-16ea-5c00-beee-c5ffda465409

DOI

10.1101/2025.06.30.662354