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Article

Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing.

Nucleic acids research - 19 Jun 2020

Saha Kaushik, England Whitney, Fernandez Mike Minh, Biswas Tapan, Spitale Robert C, Ghosh Gourisankar

Abstract excerpt

Recognition of highly degenerate mammalian splice sites by the core spliceosomal machinery is regulated by several protein factors that predominantly bind exonic splicing motifs. These are postulated to be single-stranded in order to be functional, yet knowledge of secondary structural features that regulate the exposure of exonic splicing motifs across the transcriptome is not currently available. Using...

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Identifiers

PMID: 32402057
DOI: 10.1093/nar/gkaa358
PMCID: PMC7293017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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