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Article

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

23 Jun 2021

Abstract excerpt

Purpose: Dysregulation of the alternative complement pathway is a major pathogenic mechanism in age-related macular degeneration. We investigated whether locally synthesized complement components contribute to AMD by profiling complement expression in postmortem eyes with and without AMD. Methods: AMD severity grade 1 to 4 was determined by analysis of postmortem acquired fundus images and hematoxylin and eosin...

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PMID: 34160562
DOI: 10.1167/iovs.62.7.26

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