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Article

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.

The Journal of cell biology - 2 Aug 2021

Tseng Chun-Che, Dean Shirley, Davies Brian A, Azmi Ishara F, Pashkova Natalya, Payne Johanna A, Staffenhagen Jennifer, West Matt, Piper Robert C, Odorizzi Greg, Katzmann David J

Abstract excerpt

Endosomal sorting complexes required for transport (ESCRT-0, -I, -II, -III) execute cargo sorting and intralumenal vesicle (ILV) formation during conversion of endosomes to multivesicular bodies (MVBs). The AAA-ATPase Vps4 regulates the ESCRT-III polymer to facilitate membrane remodeling and ILV scission during MVB biogenesis. Here, we show that the conserved V domain of ESCRT-associated protein Bro1 (the yeast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34160559
DOI: 10.1083/jcb.202102070
PMCID: PMC8240856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.PMID 34160559Read ↗

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles.Semantic proximity Read ↗

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The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.Semantic proximity Read ↗

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