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Article

The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.

Developmental cell - 10 Jun 2013

Pashkova Natasha, Gakhar Lokesh, Winistorfer Stanley C, Sunshine Anna B, Rich Matthew, Dunham Maitreya J, Yu Liping, Piper Robert C

Abstract excerpt

Sorting of ubiquitinated membrane proteins into lumenal vesicles of multivesicular bodies is mediated by the Endosomal Sorting Complex Required for Transport (ESCRT) apparatus and accessory proteins such as Bro1, which recruits the deubiquitinating enzyme Doa4 to remove ubiquitin from cargo. Here we propose that Bro1 works as a receptor for the selective sorting of ubiquitinated cargoes. We found synthetic...

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Identifiers

PMID: 23726974
DOI: 10.1016/j.devcel.2013.04.007
PMCID: PMC3755756

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