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Article

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.

The Journal of cell biology - 30 Aug 2004

Luhtala Natalie, Odorizzi Greg

Abstract excerpt

Ubiquitination directs the sorting of cell surface receptors and other integral membrane proteins into the multivesicular body (MVB) pathway. Cargo proteins are subsequently deubiquitinated before their enclosure within MVB vesicles. In Saccharomyces cerevisiae, Bro1 functions at a late step of MVB sorting and is required for cargo protein deubiquitination. We show that the loss of Bro1 function is suppressed by...

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Identifiers

PMID: 15326198
DOI: 10.1083/jcb.200403139
PMCID: PMC2172414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.PMID 15326198Read ↗

The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.Semantic proximity Read ↗

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway.Semantic proximity Read ↗

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.Semantic proximity Read ↗

The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast.Semantic proximity Read ↗

A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function.Semantic proximity Read ↗

The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways.Semantic proximity Read ↗

Inactivation of the VID27 gene prevents suppression of the doa4 degradation defect in doa4Δ did3Δ double mutant.Semantic proximity Read ↗

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.Semantic proximity Read ↗

The structure and function of deubiquitinases: lessons from budding yeastSemantic proximity Read ↗

Sorting Nexins in Protein HomeostasisSemantic proximity Read ↗

DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.Semantic proximity Read ↗

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