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ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress

18 Mar 2015

Abstract excerpt

Ebola (EBOV) is an enveloped, negative-sense RNA virus belonging to the family Filoviridae that causes hemorrhagic fever syndromes with high-mortality rates. To date, there are no licensed vaccines or therapeutics to control EBOV infection and prevent transmission. Consequently, the need to better understand the mechanisms that regulate virus transmission is critical to developing countermeasures. The EBOV VP40...

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PMID: 25786915
DOI: 10.1093/infdis/jiu838

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Related research

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Research trail→

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ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus EgressPMID 25786915Read ↗

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteinsSemantic proximity Read ↗

Overlapping Motifs (PTAP and PPEY) within the Ebola Virus VP40 Protein Function Independently as Late Budding Domains: Involvement of Host Proteins TSG101 and VPS-4Semantic proximity Read ↗

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate BuddingSemantic proximity Read ↗

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.Semantic proximity Read ↗

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate EgressSemantic proximity Read ↗

Host and Viral Proteins Modulating Ebola and Marburg Virus EgressSemantic proximity Read ↗

Conserved Motifs within Ebola and Marburg Virus VP40 Proteins Are Important for Stability, Localization, and Subsequent Budding of Virus-Like ParticlesSemantic proximity Read ↗

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Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate Virus-Like Particle EgressSemantic proximity Read ↗

Nedd4 Regulates Egress of Ebola Virus-Like Particles from Host CellsSemantic proximity Read ↗

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated EgressSemantic proximity Read ↗

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