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Article

Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles.

Molecular biology of the cell - 15 Mar 2010

Nickerson Daniel P, West Matthew, Henry Ryan, Odorizzi Greg

Abstract excerpt

Recruitment of endosomal sorting complexes required for transport (ESCRTs) to the cytosolic face of endosomes regulates selective inclusion of transmembrane proteins into the lumenal vesicles of multivesicular bodies (MVBs). ESCRT-0, -I, and -II bind directly to ubiquitinated transmembrane cargoes of the MVB pathway, whereas polymerization of ESCRT-III at endosomes is thought to bend the membrane and/or provide...

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Identifiers

PMID: 20089837
DOI: 10.1091/mbc.e09-09-0776
PMCID: PMC2836955

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Source receipt: pubmed, retrieved 7 Sept 2026.

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