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Article

Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formation.

The Journal of biological chemistry - 23 Dec 2011

Kallay Laura M, Brett Christopher L, Tukaye Deepali N, Wemmer Megan A, Chyou Anthony, Odorizzi Greg, Rao Rajini

Abstract excerpt

The multivesicular body (MVB) is an endosomal intermediate containing intralumenal vesicles destined for membrane protein degradation in the lysosome. In Saccharomyces cerevisiae, the MVB pathway is composed of 17 evolutionarily conserved ESCRT (endosomal sorting complex required for transport) genes grouped by their vacuole protein sorting Class E mutant phenotypes. Only one integral membrane protein, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21998311
DOI: 10.1074/jbc.M111.282319
PMCID: PMC3243563

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