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Article

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae.

Journal of cell science - 15 May 2003

Odorizzi Greg, Katzmann David J, Babst Markus, Audhya Anjon, Emr Scott D

Abstract excerpt

Multivesicular bodies are late endosomal compartments containing lumenal vesicles that are formed by inward budding of the limiting endosomal membrane. In the yeast Saccharomyces cerevisiae, integral membrane proteins are sorted into the lumenal vesicles of multivesicular bodies, and this process requires the class E subset of VPS genes. We show that one of the class E VPS genes, BRO1/VPS31, encodes a cytoplasmic...

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Identifiers

PMID: 12668726
DOI: 10.1242/jcs.00395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae.PMID 12668726Read ↗

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.Semantic proximity Read ↗

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.Semantic proximity Read ↗

Control of Bro1-domain protein Rim20 localization by external pH, ESCRT machinery, and the Saccharomyces cerevisiae Rim101 pathway.Semantic proximity Read ↗

The beta domain is required for Vps4p oligomerization into a functionally active ATPase.Semantic proximity Read ↗

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis.Semantic proximity Read ↗

Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formation.Semantic proximity Read ↗

The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.Semantic proximity Read ↗

Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites.Semantic proximity Read ↗

Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The Saccharomyces cerevisiae MVP1 gene interacts with VPS1 and is required for vacuolar protein sorting.Semantic proximity Read ↗

The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturationSemantic proximity Read ↗

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