Article
RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif.
Cell death and differentiation - 1 Jan 2021
Hu Hong, Wu Xialian, Wu Guoxiang, Nan Ning, Zhang Jing, Zhu Xinxin, Zhang Yu, Shu Zhaoqian, Liu Jia, Liu Xiaoyan, Lu Junxia, Wang Huayi
Abstract excerpt
Necroptosis is mediated by signaling complexes called necrosomes, which contain receptor-interacting protein 3 (RIP3) and upstream effectors, such as RIP1. In necrosomes, the RIP homotypic interaction motif (RHIM) of RIP3 and RIP1 forms amyloidal complex. But how the amyloidal necrosomes control RIP3 activation and cell necroptosis has not been determined. Here, we showed that RIP3 amyloid fibrils could further...
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