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Article

Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism

22 Jun 2021

Abstract excerpt

Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. Esrrg deficiency impaired the maintenance and function of Tregs, leading to global T cell activation and autoimmunity in aged mice. Further, Esrrg-deficient Tregs presented an impaired differentiation into follicular Tregs that...

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PMID: 34156979
DOI: 10.1172/jci.insight.143540

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