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Article

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.

Journal of leukocyte biology - 1 Dec 2022

Ma Chi, Hoffmann FuKun W, Nunes Lance G, Urena Frank, Andrukhiv Anastasia, Gerschenson Mariana, Pitts Matthew W, Hoffmann Peter R

Abstract excerpt

Selenoprotein I (SELENOI) is an ethanolamine phospholipid transferase contributing to cellular metabolism and the synthesis of glycosylphosphatidylinositol (GPI) anchors. SELENOI knockout (KO) in T cells has been shown to impair metabolic reprogramming during T cell activation and reduce GPI-anchored Thy-1 levels, which are both crucial for Th17 differentiation. This suggests SELENOI may be important for Th17...

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Identifiers

PMID: 35916034
DOI: 10.1002/JLB.1A0122-080R
PMCID: PMC9701159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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