Article
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.
The Journal of experimental medicine - 3 Nov 2025
Xu Jinjin, Kong Lingjia, Creasey Elizabeth A, Rath Sneha, Deng Lei, Avila-Pacheco Julian, Li Chenhao, Oliver Blayne A, Dao Tyler T, Shih Angela R, Daly Mark J, Shalek Alex K, Clish Clary B, Graham Daniel B, Deguine Jacques, Xavier Ramnik J
Abstract excerpt
Genome-wide association studies (GWAS) have linked the locus encoding ankyrin repeat domain 55 (ANKRD55) with numerous autoimmune diseases; however, its biological function and role in inflammation are unclear. Here, we demonstrate that Ankrd55-deficient mice are protected from T cell-mediated colitis but are more susceptible to Citrobacter rodentium infection. Mechanistically, Ankrd55 deletion impairs CD4+ T...
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