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Article

Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function.

Cell reports - 6 Jul 2021

Katsuyama Takayuki, Moulton Vaishali R

Abstract excerpt

The ability of regulatory T (Treg) cells to control the immune response and limit the development of autoimmune diseases is determined by distinct molecular processes, which are not fully understood. We show here that serine/arginine-rich splicing factor 1 (SRSF1), which is decreased in T cells from patients with systemic lupus erythematosus, is necessary for the homeostasis and proper function of Treg cells,...

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Identifiers

PMID: 34233194
DOI: 10.1016/j.celrep.2021.109339
PMCID: PMC8476088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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