Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.

doi:10.1172/jci.insight.134010

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.

JCI insight - 16 Jan 2020

Godavarthy Aparna, Kelly Ryan, Jimah John, Beckford Miguel, Caza Tiffany, Fernandez David, Huang Nick, Duarte Manuel, Lewis Joshua, Fadel Hind J, Poeschla Eric M, Banki Katalin, Perl Andras

Abstract excerpt

Overexpression and long terminal repeat (LTR) polymorphism of the HRES‑1/Rab4 human endogenous retrovirus locus have been associated with T cell activation and disease manifestations in systemic lupus erythematosus (SLE). Although genomic DNA methylation is diminished overall in SLE, its role in HRES-1/Rab4 expression is unknown. Therefore, we determined how lupus-associated polymorphic rs451401 alleles of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to Endogenous Retroviruses

Share to HCT116 Cells

Share to Lupus Erythematosus, Systemic

Share to Receptors, Antigen, T-Cell

Share to Terminal Repeat Sequences

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 31805010
DOI: 10.1172/jci.insight.134010
PMCID: PMC7030820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation.PMID 31805010Read ↗

DNA methylation modulates HRES1/p28 expression in B cells from patients with LupusSemantic proximity Read ↗

Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLESemantic proximity Read ↗

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosusSemantic proximity Read ↗

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus.Semantic proximity Read ↗

LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosusSemantic proximity Read ↗

Immunometabolism in the pathogenesis of systemic lupus erythematosus: an updateSemantic proximity Read ↗

Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolismSemantic proximity Read ↗

Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition.Semantic proximity Read ↗

RSAD2/VIPERIN and CMPK2 Coordinate an Immunometabolic Response to Epstein-Barr VirusSemantic proximity Read ↗

Activity of the LMP1 gene promoter in Epstein-Barr virus-transformed cell lines is modulated by sequence variations in the promoter-proximal CRE site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.