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Article

Functional dissection of phosphorylation of Disheveled in Drosophila.

Developmental biology - 1 Dec 2011

Yanfeng Wang A, Berhane Hebist, Mola Marion, Singh Jaskirat, Jenny Andreas, Mlodzik Marek

Abstract excerpt

Disheveled/Dsh proteins (Dvl in mammals) are core components of both Wnt/Wg-signaling pathways: canonical β-catenin signaling and Frizzled (Fz)-planar cell polarity (PCP) signaling. Although Dsh is a key cytoplasmic component of both Wnt/Fz-pathways, regulation of its signaling specificity is not well understood. Dsh is phosphorylated, but the functional significance of its phosphorylation remains unclear. We...

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Identifiers

PMID: 21963539
DOI: 10.1016/j.ydbio.2011.09.017
PMCID: PMC3221411

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