Article
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
Genes & development - 15 Aug 1998
Axelrod J D, Miller J R, Shulman J M, Moon R T, Perrimon N
Abstract excerpt
In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor. Using a heterologous system, we show that Dsh is recruited selectively to the membrane b...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Biological Transport
- Cell Membrane
- Cell Polarity
- Cloning, Molecular
- Cytoplasm
- Dishevelled Proteins
- Drosophila
- Drosophila Proteins
- Frizzled Receptors
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Proto-Oncogene Proteins
- Receptors, G-Protein-Coupled