Article

Contributing factors on metabolic mechanism-based CYP3A4-activated/deactivated anticancer drugs: implications for individualizing chemotherapy

2022-06-11

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4), one of important members of the cytochrome P450 subfamily, acts as a critical catalyst for multiple drug metabolism. Pharmacological activities and clinical outcomes of CYP3A4-metabolized anticancer drugs greatly depend on this enzyme activity and expression, as it catalyzes a variety of reactions for drug activation or inactivation. In view of the complex tumor environments as well a...

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Literature Corpus work: e95bf879-055c-59a2-a65b-f92269be7b14
DOI: 10.22541/au.165494170.08151812/v1

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