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Article

Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Dec 2021

Song Haojing, Bai Wanjun, Sun Xue, Qiu Bo, Guo Nini, Guo Caihui, Hu Yiting, Dong Zhanjun

Abstract excerpt

The aim of this study was to evaluate the impact of genetic polymorphisms in the pharmacokinetics of metabolism and transportation of lenvatinib in the Chinese population.Sixty-three healthy Chinese individuals were recruited and administered with a single dose of 4 mg lenvatinib. Allelic discriminations for 10 SNPs of CYP3A4 (20230 G>A(*1G)), CYP3A5 (6986 A>G(*3)), ABCB1 (1236 C>T, 2677 G>T/A, 3435 C>T), ABCG2...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34979850
DOI: 10.1080/00498254.2021.2023913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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