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Genome-Wide Approach to Measure Variant-Based Heritability of Drug Outcome Phenotypes.

Clinical pharmacology and therapeutics - 1 Sept 2021

Muhammad Ayesha, Aka Ida T, Birdwell Kelly A, Gordon Adam S, Roden Dan M, Wei Wei-Qi, Mosley Jonathan D, Van Driest Sara L

Abstract excerpt

Pharmacogenomic studies have successfully identified variants-typically with large effect sizes in drug target and metabolism enzymes-that predict drug outcome phenotypes. However, these variants may account for a limited proportion of phenotype variability attributable to the genome. Using genome-wide common variation, we measured the narrow-sense heritability ( h SNP 2 ) of seven pharmacodynamic and five...

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PMID: 34151428
DOI: 10.1002/cpt.2323
PMCID: PMC8376753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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