Article

Phenome-wide association studies (PheWAS) across large “real-world data” population cohorts support drug target validation

2017-11-13

Abstract excerpt

Phenome-wide association studies (PheWAS), which assess whether a genetic variant is associated with multiple phenotypes across a phenotypic spectrum, have been proposed as a possible aid to drug development through elucidating mechanisms of action, identifying alternative indications, or predicting adverse drug events (ADEs). Here, we evaluate whether PheWAS can inform target validation during drug development. W...

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Literature Corpus work: bd00f097-adfd-551a-87b2-aca39f40b808
DOI: 10.1101/218875

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