Microsatellite instability in non-endometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes.

doi:10.1016/j.trsl.2023.05.004

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Article

Microsatellite instability in non-endometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes.

Translational research : the journal of laboratory and clinical medicine - 1 Oct 2023

Hájková Nikola, Bártů Michaela Kendall, Cibula David, Drozenová Jana, Fabian Pavel, Fadare Oluwole, Frühauf Filip, Hausnerová Jitka, Hojný Jan, Krkavcová Eva, Laco Jan, Lax Sigurd F, Matěj Radoslav, Méhes Gábor, Michálková Romana, Němejcová Kristýna, Singh Naveena, Stolnicu Simona, Švajdler Marián, Zima Tomáš, McCluggage Wilson Glenn, Stružinská Ivana, Dundr Pavel

Abstract excerpt

Testing of microsatellite instability is not only used as a triage for possible Lynch syndrome, but also to predict immunotherapy treatment response. The aim of this study was to assess the frequency of mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) in 400 cases of non-endometrioid ovarian tumors (high-grade serous, low-grade serous, mucinous and clear cell), to compare different...

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PMID: 37244485
DOI: 10.1016/j.trsl.2023.05.004

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