Article
Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas.
Gynecologic oncology - 1 May 2015
McConechy M K, Talhouk A, Li-Chang H H, Leung S, Huntsman D G, Gilks C B, McAlpine J N
Abstract excerpt
BACKGROUND: A proportion of endometrial carcinomas (ECs) are associated with deficient DNA mismatch repair (MMR). These tumors are characterized by high levels of microsatellite instability (MSI). Identification of MSI is important in identifying women who should be tested for Lynch syndrome and identifying a phenotype that may have specific prognostic and predictive implications. Genomic characterization of ECs...
Topics
Join the communities discussing this publication.