Article

Detection of Mismatch Repair Deficiency in Endometrial Cancer: Comparison of IHC, Fragment Length Analysis, and Amplicon Sequencing Based MSI Testing

2024-10-08

Abstract excerpt

Mismatch repair (MMR) deficiency can be indicative of Lynch syndrome (LS) and guide treatment with immune checkpoint inhibitors. Colorectal cancers (CRCs) and endometrial cancers (ECs) are routinely screened to identify LS, primarily using immunohistochemistry (IHC) or Microsatellite Instability (MSI) testing, but concordance between methods is variable in ECs. Here, we investigate this variability by using the am...

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Literature Corpus work: 48e28cf2-cc6f-58b7-b868-1ed4f9c81606
DOI: 10.20944/preprints202410.0560.v1

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