Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2021

Sakai Shohei, Watanabe Seiji, Komine Okiru, Sobue Akira, Yamanaka Koji

Abstract excerpt

The mitochondria-associated membrane (MAM) is a functional subdomain of the endoplasmic reticulum membrane that tethers to the mitochondrial outer membrane and is essential for cellular homeostasis. A defect in MAM is involved in various neurological diseases, including amyotrophic lateral sclerosis (ALS). Recently, we and others reported that MAM was disrupted in the models expressing several ALS-linked genes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Amyotrophic Lateral Sclerosis Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Membranes

Share to Mitochondrial Proteins

Share to Mutation

Share to Neuroblastoma

Source

Identifiers

PMID: 34143516
DOI: 10.1096/fj.202100137R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.PMID 34143516Read ↗

Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.Semantic proximity Read ↗

A role for mitochondria-ER crosstalk in amyotrophic lateral sclerosis 8 pathogenesis.Semantic proximity Read ↗

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALSSemantic proximity Read ↗

ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.Semantic proximity Read ↗

Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.Semantic proximity Read ↗

Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration.Semantic proximity Read ↗

Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosisSemantic proximity Read ↗

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.Semantic proximity Read ↗

A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum.Semantic proximity Read ↗

Convergent activation of the integrated stress response and ER–mitochondria uncoupling in VAPB-associated ALSSemantic proximity Read ↗

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALSSemantic proximity Read ↗

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.