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Article

ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.

International journal of molecular sciences - 13 Oct 2020

Tak Yeong Jin, Park Ju-Hwang, Rhim Hyangshuk, Kang Seongman

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive demise of motor neurons. One of the causes of familial ALS is the mutation of the gene encoding superoxide dismutase 1 (SOD1), which leads to abnormal protein aggregates. How SOD1 aggregation drives ALS is still poorly understood. Recently, ALS pathogenesis has been functionally implicated in mitophagy,...

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Identifiers

PMID: 33065963
DOI: 10.3390/ijms21207525
PMCID: PMC7590160

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ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin.PMID 33065963Read ↗

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