Article

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Mitochondria-associated ER membranes (MAM) are transient functional domains in the endoplasmic reticulum (ER) in close apposition to mitochondria involved in multiple metabolic functions, including the regulation of mitochondria functionality. Specifically, MAM interactions with mitochondria contribute to the regulation of mitochondrial dynamics, calcium transference between both organe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 764e07bf-1acb-58f0-99df-4a7bf4995022
DOI: 10.21203/rs.3.rs-2187007/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALSDOI 10.21203/rs.3.rs-2187007/v1Read

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALSSemantic proximity Read

Aberrant ER-mitochondria communication is a common pathomechanism in mitochondrial disease.Semantic proximity Read

The Wolfram-like variant WFS1 <sup>E864K</sup> destabilizes MAM and compromises autophagy and mitophagy in human and miceSemantic proximity Read

The Wolfram-like variant WFS1 E864K destabilizes MAM and compromises autophagy and mitophagy in human and miceSemantic proximity Read

ERAD deficiency disrupts mitochondrial bioenergetics by altering MAM Ca2+ in human hepatic cellsSemantic proximity Read

Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.Semantic proximity Read

Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome.Semantic proximity Read

ER Calcium Depletion as a Key Driver for Impaired ER-to-Mitochondria Calcium Transfer and Mitochondrial Dysfunction in Wolfram SyndromeSemantic proximity Read

ALS Motor Neurons Exhibit Hallmark Metabolic Defects That Are Rescued by Nicotinamide and SIRT3 ActivationSemantic proximity Read

Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function.Semantic proximity Read

Presenilin 1 (PS1) located at mitochondrial inner membrane regulates mitochondrial cristae junction proteins arrangement and cristae formation in HEK293 cellsSemantic proximity Read

Metabolic Changes Associated With Muscle Expression of SOD1G93ASemantic proximity Read