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Article

Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2021

Kamemura Kosuke, Chen Chun-An, Okumura Misako, Miura Masayuki, Chihara Takahiro

Abstract excerpt

VAMP-associated protein (VAP) is an endoplasmic reticulum (ER) membrane protein that functions as a tethering protein at the membrane contact sites between the ER and various intracellular organelles. Mutations such as P56S in human VAPB cause neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). However, VAP functions in neurons are poorly understood. Here, we utilized Drosophila olfactory...

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PMID: 33548103
DOI: 10.1111/gtc.12835

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Amyotrophic lateral sclerosis-associated Vap33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.PMID 33548103Read ↗

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.Semantic proximity Read ↗

The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum.Semantic proximity Read ↗

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.Semantic proximity Read ↗

Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment.Semantic proximity Read ↗

VAP Proteins – From Organelle Tethers to Pathogenic Host Interactors and Their Role in Neuronal DiseaseSemantic proximity Read ↗

A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect.Semantic proximity Read ↗

ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.Semantic proximity Read ↗

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).Semantic proximity Read ↗

Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?Semantic proximity Read ↗

Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.Semantic proximity Read ↗

Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic responseSemantic proximity Read ↗

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