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Article

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.

Neurobiology of disease - 1 Mar 2026

Hnath Brianna, Ekambaram Srinivasan, Dokholyan Nikolay V

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results in paralysis and death within three to five years. Mutations in over forty different proteins have been linked to ALS, raising debate over whether ALS is a single disease or multiple disorders with similar symptoms. Mutations in Cu,Zn superoxide dismutase 1 (SOD1) are found in only 2-3% of ALS cases, yet misfolded SOD1 appears...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41651252
DOI: 10.1016/j.nbd.2026.107309
PMCID: PMC13064919

Genes

SOD1
CD9
FUS
VAPB
VCP

Provenance

PubMed metadata and Literature Corpus relationships.

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