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Article

Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions

16 Apr 2021

Abstract excerpt

Adverse drug reactions (ADRs) remain associated with significant mortality. Delayed hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration are T-cell mediated with many severe DHRs now associated with human leukocyte antigen (HLA) risk alleles, opening pathways for clinical prediction and prevention. However, incomplete negative predictive value (NPV), low positive predictive...

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PMID: 33936169
DOI: 10.3389/fgene.2021.641905

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