Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions.

Current opinion in immunology - 1 Oct 2016

Illing Patricia T, Mifsud Nicole A, Purcell Anthony W

Abstract excerpt

It is hypothesised that associations between adverse drug reactions and specific alleles of the human leukocyte antigens arise due to specific interactions between the human leukocyte antigen molecules and the causative drug that stimulate immune responses targeting drug exposed tissues. To date this has only been definitively demonstrated for abacavir, an antiretroviral that causes a systemic adverse drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Dideoxynucleosides
Share to Drug Hypersensitivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to HLA-B Antigens

Share to Hypersensitivity, Delayed

Share to Polymorphism, Genetic

Share to T-Lymphocytes

Source

Identifiers

PMID: 27261882
DOI: 10.1016/j.coi.2016.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions.PMID 27261882Read ↗

Immunopharmacogenomics: Mechanisms of HLA-Associated Drug Reactions.Semantic proximity Read ↗

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.Semantic proximity Read ↗

HLA and pharmacogenetics of drug hypersensitivity.Semantic proximity Read ↗

HLA alleles and drug hypersensitivity reactions.Semantic proximity Read ↗

Activation of CD8+ T-Cell with abacavir and HLA-B*57:01 binding peptides and elimination of T-Cell responses through chemical modificationSemantic proximity Read ↗

Pharmacogenetics of hypersensitivity drug reactions.Semantic proximity Read ↗

HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.Semantic proximity Read ↗

T Cell–Mediated Hypersensitivity Reactions to DrugsSemantic proximity Read ↗

Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.Semantic proximity Read ↗

Hypersensitivity reactions to HIV therapy.Semantic proximity Read ↗

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivitySemantic proximity Read ↗

Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.