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Article

Paired analysis of tumor mutation burden for lung adenocarcinoma and associated idiopathic pulmonary fibrosis.

Scientific reports - 17 Jun 2021

Yoneshima Yasuto, Iwama Eiji, Matsumoto Shingo, Matsubara Taichi, Tagawa Testuzo, Ota Keiichi, Tanaka Kentaro, Takenoyama Mitsuhiro, Okamoto Tatsuro, Goto Koichi, Mori Masaki, Okamoto Isamu

Abstract excerpt

Genetic alterations underlying the development of lung cancer in individuals with idiopathic pulmonary fibrosis (IPF) have remained unclear. To explore whether genetic alterations in IPF tissue contribute to the development of IPF-associated lung cancer, we here evaluated tumor mutation burden (TMB) and somatic variants in 14 paired IPF and tumor samples from patients with IPF-associated lung adenocarcinoma. We...

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Identifiers

PMID: 34140559
DOI: 10.1038/s41598-021-92098-y
PMCID: PMC8211684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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